姓        名：康岚

学        位：博士

导师情况：博士生导师

研究领域：干细胞生物学，发育生物学

研究方向：

      1、早期胚胎发育中的表观调控机制。

      2、生殖类器官技术及应用。     

E-mail: kanglan@tongji.edu.cn
联系电话：021-65987363
通讯地址：上海市四平路1230号同济大学东区A楼708室

个人简历：

研究方向简介：

康岚博士长期从事干细胞和早期胚胎发育机制研究，先后主持国自然优秀青年、国家重点研发子课题等项目，以第一作者或通讯作者在Cell Stem Cell，Cell Research，Nature Communications，Protein & Cell等期刊上发表二十余篇论文，累计引用600余次。

      
 代表性论文：  

1. Liu J*, Yang J*, Ye W*, Yang D, Su N, Wang H, Zhang Y#, Gao S#, Kang L#. LncRNA Gas5 directs SUV39H2 to establish heterochromatin and maintain genome stability. Protein Cell 2026 Jun 23:pwag039. (Correspondence author) (2026)

2. Zhang D*, Tang Y*, Ye W*, Yang D, Qin S, Liu J, Su N, Huang R, Shi G, Xu D, Kou X, Zhao Y, Wang H, Gao S#, Wei K#, Kang L#. PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability. National Science Review 13(1): nwaf408. (Correspondence author) (2025)

3. Zhang J*, Xiang S*, Liu D*, Pei X*, Chen M, Zhao Y, Wang Y, Wang Q, Kang L#, Yu Z#, Mi J#, Xiong W#. KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers. Cell Death and Disease 16(1):523. (Co-correspondence author) (2025)

4. Wu L*, Shen J, Hou Z, Zhang Y, Bi Y, Zhang R, Bai H, Ye W, Chen K, Zhu J, Xi C, Xu Y, Kou X, Zhao Y, Li C, Fan H, Le R, Wang Y, Xu X, Xu S, Wang H, Gao S#, Kang L#. Obox1 deficiency impairs fertility in female mice. Fundamental Research 67(5):958-969. (Correspondence author) (2025)

5. Chen K*, Liu W*, Zhu J*, Kou X, Zhao Y, Wang H, Jiang C#, Gao S#, Kang L#. Pivotal role for long noncoding RNAs in zygotic genome activation in mice. Science China Life Sciences 67(5):958-969. (Correspondence author) (2024)

6. Zhu J*, Chen K*, Sun Y*, Ye W, Liu J, Zhang D, Su N, Kou X, Zhao Y, Wang H, Gao S#, Kang L#. LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei. Nature Communications 14(1):957. (Correspondence author) (2023)

7. Wu L*, He S*, Ye W, Shen J, Zhao K, Zhang Y, Zhang R, Wei J, Cao S, Chen K, Le R, Xi C, Kou X, Zhao Y, Wang H, Kang L#, Gao S#. Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. Cell Proliferation 54(11):e13133. (Co-correspondence author) (2021)

8. He J*, Ye W*, Kou N*, Chen K, Cui B, Zhang X, Hu S, Liu T#, Kang L#, Li X#. MicroRNA-29b-3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway. Journal of Cellular and Molecular Medicine 24(1):841-849. (Co-correspondence author) (2020)

9. Kang L*, Chen J*, Gao S#. Historical review of reprogramming and pluripotent stem cell research in China. Yi Chuan 40(10):825-840. (First author) (2018)

10. Wu L*, Wu Y, Peng B, Hou Z, Dong Y, Chen K, Guo M, Li H, Chen X, Kou X, Zhao Y, Bi Y, Wang Y, Wang H, Le R, Kang L#, Gao S#. Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation. Stem Cell Reports 9(5):1692-1705. (Co-correspondence author) (2017)

11. Li X*, Ma C*, Zhang L*, Li N, Zhang X, He J, He R, Shao M, Wang J, Kang L#, Han C#. LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression. Cancer Letter 407:45-56. (Co-correspondence author) (2017)

12. Qin S*, Yang D*, Chen K, Li H, Zhang L, Li Y, Le R, Li X, Gao S# and Kang L#. Pkm2 can enhance pluripotency in ESCs and promote somatic cell reprogramming to iPSCs. Oncotarget 8:84276-84284. (Co-correspondence author) (2017)

13. Feng X*, Xu X*, Xiao X*, Zou K*, Yu W, Wu J, Tang R, Gao Y, Hao J, Zhao X, Liao Y, Chen Y, Huang W, Guo W#, Kang L#, Deng W#. NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. Cell Death & Disease 8(5):e2783. (Co-correspondence author) (2017)

14. Wang M*, Zhang Y*, Wang T, Zhang J, Zhou Z, Sun Y, Wang S, Shi Y, Luan X, Zhang Y, Wang Y, Wang Y, Zou Z, Kang L#, Liu H#. The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status. Cellular Physiology and Biochemistry 43(5):1755-1766. (Co-correspondence author) (2015)

15. Hao J*, Xu H*, Luo M*, Yu W*, Chen M, Liao Y, Zhang C, Zhao X, Jiang W, Hou S, Feng X, Zou K, Chen Y, Huang W, Guo W#, Kang L#, Deng W#. The tumor-promoting role of TRIP4 in melanoma progression and its involvement in response to BRAF-targeted therapy. Journal of Investigative Dermatology 138(1):159-170. (Co-correspondence author) (2017)

16. Kang L*, Gao S#. Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation. Methods in Molecular Biology 1330:125-32. (First author) (2015)

17. Kang L*, Wu J*, Tao Y*, Li H, Liu X, Gao S#, Wang Q#. Cell Type-Specific Expression Profile and Signaling Requirements in Early Hematopoietic Reprogramming. Stem Cells and Development 24(12):1483-92. (First author & Co-correspondence author) (2015)

18. Kang L*, Gao S#. Pluripotency of induced pluripotent stem cells. Journal of Animal Science and Biotechnology 28;3(1):5. (First author) (2012)

19. Kang L*, Wu T, Tao Y, Yuan Y, He J, Zhang Y, Luo T, Kou Z, Gao S#. Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation. Cell Research 21(3):546-9. (First author) (2011)

20. Kang L*, Kou Z, Zhang Y, Gao S#. Induced pluripotent stem cells (iPSCs)--a new era of reprogramming. Journal of Genetics and Genomics 7(7):415-21 (2010). (First author)

21. Kou Z*, Kang L*, Yuan Y, Tao Y, Zhang Y, Wu T, He J, Wang J, Liu Z, Gao S#. Mice cloned from induced pluripotent stem cells (iPSCs). Biology of Reproduction 83(2):238-43. (Co-first author) (2010)

22. Kang L*, Wang J, Zhang Y, Kou Z, Gao S#. iPS cells can support full term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2):135-138. (First author) (2009)