姓        名：刘文强

学        位：博士

导师情况：博士生导师

研究领域：发育与生殖生物学

研究方向：

1．哺乳动物及人早期胚胎发育调控。 
2．胚胎发育异常的机制及干预。 
3．不育不孕的遗传学机制及辅助生殖技术。
E-mail：liuwenqiang@tongji.edu.cn
联系电话：021-65982276
通讯地址：上海市四平路1239号开云官方网站登录入口
实验室网址：gaolab.tongji.edu.cn
 

个人简介:

刘文强，开云官方网站登录入口/同济大学附属妇产科医院，教授，国家级高层次人才。上海市母胎医学与妇科肿瘤研究所副所长，科技部重点研发计划（青年）首席科学家。入选上海市青年拔尖人才计划、上海市科技启明星计划。获同济大学“青年五四奖章”。

2007年毕业于西北农林科技大学，获学士学位；2010年毕业于西北农林科技大学，获硕士学位；2014年毕业于中国农业大学/北京生命科学研究所，获博士学位；2014年8月至今任职于同济大学/同济大学附属妇产科医院。致力于早期胚胎发育调控与辅助生殖技术研究，构建了植入期类胚胎体外研究体系，解析了早期胚胎关键表观重塑规律与胚胎植入失败的表观遗传机制。近年来在Nature，Cell Stem Cell，Nature Cell Biology，Cell Research等杂志发表论文 40 余篇。研究成果获教育部自然科学奖一等奖，中华医学科技奖二等奖。

发表论文：

(1) Kuisheng Liu#; Zihui Yan#; Dandan Bai#; Rui Jiang#; Yan Bi#; Xiangjun Ma#; Jiani Xiang; Yifan Sheng; Baoxing Dong; Zhiyuan Ning; Shanru Yi; Yingdong Liu; Xinyi Lei; Yanping Jia; Yan Zhang; Yalin Zhang; Yanhe Li; Tao Wu; Chenxiang Xi; Shanyao Liu; Shuyi Liu; Jiayu Chen; Jiqing Yin; Xiaochen Kou; Yanhong Zhao; Hong Wang; Yixuan Wang*; Ke Wei*; Shaorong Gao*; Wenqiang Liu*; Modeling post-gastrula development via bidirectional pluripotent stem cells, Cell Research, 2025, 35(12): 954-969

(2) Yanhe Li#; Jincan He#; Yingdong Liu; Yi Hui; Shanyao Liu; Yalin Zhang; Yan Xiong; Tingting Xu; Ziwen Xu; Zhuoao Zhang; Yan Zhang; Guang Yang; Jia Zhao; Dandan Bai; Xinyi Lei; Xiaochen Kou; Yanhong Zhao; Jing Du; Zheng Guo; Jiqing Yin; Xiaoqing Zhang; Congling Xu; Yawei Gao; Miaoxin Chen; Hong Wang; Cizhong Jiang*; Shaorong Gao*; Wenqiang Liu*; Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis, Nature Cell Biology, 2025, 27(10): 1797-1811

(3) Yanping Jia#; Yingdong Liu#; Yanhe Li#; Xiaohong Guan#; Junting Xu; Zihui Yan; Kuisheng Liu; Yalin Zhang; Dandan Bai; Jiani Xiang; Yan Zhang; Shangyu Hou; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Hong Wang; Kunming Li*; Shaorong Gao*; Wenqiang Liu*; Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism, Science Bulletin, 2025, 70(14): 2297-2311

(4) Hui Yang#; Dandan Bai#; Yanhe Li#; Zhaowei Yu#; Chenfei Wang; Yifan Sheng; Wenqiang Liu*; Shaorong Gao*; Yong Zhang*; Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo, Nature Cell Biology, 2022, 24(5): 789-792

(5) Dandan Bai#; Jin Sun#; Chuan Chen; Yanping Jia; Yanhe Li; Kuisheng Liu; Yalin Zhang; Jiqing Yin; Yingdong Liu; Xiaoxiao Han; Jingling Ruan; Xiaochen Kou; Yanhong Zhao; Hong Wang; Zheng Wang; Miaoxin Chen; Xiaoming Teng; Cizhong Jiang*; Shaorong Gao*; Wenqiang Liu*; Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos, Cell Reports, 2022, 39(5): 110784

(6) Rui Gao#; Chenfei Wang#; Yawei Gao#; Wenchao Xiu; Jiayu Chen; Xiaochen Kou; Yanhong Zhao; Yuhan Liao; Dandan Bai; Zhibin Qiao; Lei Yang; Mingzhu Wang; Ruge Zang; Xiaoyu Liu; Yanping Jia; Yanhe Li; Yalin Zhang; Jiqing Yin; Hong Wang; Xiaoping Wan; Wenqiang Liu*; Yong Zhang*; Shaorong Gao*; Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos, Cell Stem Cell, 2018, 23(3): 426-435

(7) Kuisheng Liu#; Xiaocui Xu#; Dandan Bai#; Yanhe Li; Yalin Zhang; Yanping Jia; Mingyue Guo; Xiaoxiao Han; Yingdong Liu; Yifan Sheng; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Sheng Liu; Jiayu Chen; Hong Wang; Yixuan Wang; Wenqiang Liu*; Shaorong Gao*; Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Protein & Cell, 2023, 14(4): 262-278

(8) Yanhe Li#; Caihong Zheng#; Yingdong Liu; Jincan He; Qiang Zhang; Yalin Zhang; Xiaochen Kou; Yanhong Zhao; Kuisheng Liu; Dandan Bai; Yanping Jia; Xiaoxiao Han; Yifan Sheng; Jiqing Yin; Hong Wang; Shuai Gao; Wenqiang Liu*; Shaorong Gao*; Inhibition of Wnt activity improves periimplantation development of somatic cell nuclear transfer embryos, National Science Review, 2023, 10(9): nwad173

(9) Guang Yang#; Linfeng Zhang#; Wenqiang Liu#; Zhibin Qiao; Shijun Shen; Qianshu Zhu; Rui Gao; Mengting Wang; Mingzhu Wang; Chong Li; Meng Liu; Jin Sun; Liping Wang; Wenju Liu; Xinyu Cui; Kun Zhao; Ruge Zang; Mo Chen; Zehang Liang; Lu Wang; Xiaochen Kou; Yanhong Zhao; Hong Wang; Yixuan Wang; Shaorong Gao*; Jiayu Chen*; Cizhong Jiang*; Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer, Cell Stem Cell, 2021, 28(1): 150-163

(10) Chengchen Zhao#; Naiqian Zhang#; Yalin Zhang#; Nuermaimaiti Tuersunjiang; Shaorong Gao; Wenqiang Liu*; Yong Zhang*; A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos, Genome Biology, 2020, 21(1)

(11) Yanhe Li; Yuteng Weng; Dandan Bai; Yanping Jia; Yingdong Liu; Yalin Zhang; Xiaochen Kou; Yanhong Zhao; Jingling Ruan; Jiayu Chen; Jiqing Yin; Hong Wang; Xiaoming Teng; Zuolin Wang; Wenqiang Liu*; Shaorong Gao*; Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation, Nature Communications, 2020, 11(1): 4593

(12) Wenqiang Liu#; Xiaoyu Liu#; Chenfei Wang#; Yawei Gao#; Rui Gao; Xiaochen Kou; Yanhong Zhao; Jingyi Li; You Wu; Wenchao Xiu; Su Wang; Jiqing Yin; Wei Liu; Tao Cai; Hong Wang; Yong Zhang*; Shaorong Gao*; Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing, Cell Discovery, 2016, 2(7): 16010-16010

(13) Xiaoyu Liu#; Chenfei Wang#; Wenqiang Liu#; Jingyi Li#; Chong Li; Xiaochen Kou; Jiayu Chen; Yanhong Zhao; Haibo Gao; Hong Wang; Yong Zhang*; Yawei Gao*; Shaorong Gao*; Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos, Nature, 2016, 537(7621): 558-562